TSPY8

Across TCGA patient cohorts, TSPY8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,446 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TSPY8-associated GO terms across cancer lineages are Macromolecule methylation, Negative regulation of response to cytokine stimulus, and Proton-transporting V-type ATPase complex assembly. Each is linked with TSPY8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPY8-to-partner and partner-to-TSPY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macromolecule methylation grouped by TSPY8-low versus TSPY8-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPY8→partner) and Y-score (partner→TSPY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Macromolecule methylation →	+0.024	+0.759	<.001	<.001	3	2
TGCT	Negative regulation of response to cytokine stimulus →	+0.035	+0.521	<.001	<.001	3	2
TGCT	Proton-transporting V-type ATPase complex assembly →	+0.065	+0.488	<.001	<.001	3	2
TGCT	Vacuolar proton-transporting V-type ATPase complex assembly →	+0.066	+0.441	<.001	<.001	3	2
LIHC	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.040	+0.023	<.001	.005	2	2
LIHC	Protein processing →	+0.021	+0.023	<.001	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,446 associations by consensus.

Macromolecule methylation by TSPY8 expression — TGCT

Explore this box plot interactively →