TSPY1

Across TCGA cell cohorts, TSPY1 RNA expression is significantly associated with the mutation status of many other genes, with 45 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TSPY1-associated genes across cancer lineages are DOT1L, KMT2C, and ARHGEF1. Each is linked with TSPY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPY1-to-partner and partner-to-TSPY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOT1L grouped by TSPY1-low versus TSPY1-high in LUNG_NSCLC_LUAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPY1→partner) and Y-score (partner→TSPY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DOT1L →	+4.078	+1.016	.009	<.001	3	2
LUNG_SCLC	KMT2C →	+2.459	+0.794	.004	.001	3	2
BLOOD_Lymphoma	ARHGEF1 →	+4.247	+0.010	.004	<.001	3	1
LUNG_NSCLC_LUAD	NUP98 →	+4.662	+1.292	.005	<.001	3	1
LUNG_NSCLC_LUAD	SNED1 →	+4.078	+1.016	.009	<.001	3	1
LUNG_NSCLC_LUAD	ZNF592 →	+4.078	+1.016	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

DOT1L by TSPY1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →