TSPO2

Across TCGA patient cohorts, TSPO2 mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPO2-associated genes across cancer lineages are RNU6-986P, RNA5SP232, and OR5D3P. Each is linked with TSPO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPO2-to-partner and partner-to-TSPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-986P grouped by TSPO2-low versus TSPO2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPO2→partner) and Y-score (partner→TSPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-986P →	+0.704	+4.271	<.001	.003	3	2
BRCA	RNA5SP232 →	+0.259	+8.055	.004	.007	3	2
COAD	OR5D3P →	+0.066	+5.332	<.001	.002	3	1
COAD	TRGJP1 →	+0.789	+3.754	<.001	.008	3	1
COAD	RPS15AP3 →	+0.189	+4.418	<.001	.008	3	1
COAD	MDH1P2 →	+0.098	+3.792	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

RNU6-986P by TSPO2 expression — COAD

Explore this box plot interactively →