TSPO2

Across TCGA patient cohorts, TSPO2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPO2-associated genes across cancer lineages are A-Raf_pS299, Fibronectin, and MEK1. Each is linked with TSPO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPO2-to-partner and partner-to-TSPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TSPO2-low versus TSPO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPO2→partner) and Y-score (partner→TSPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.125	-3.169	.024	.019	3	1
UCEC	Fibronectin →	-0.355	-3.312	.020	.010	3	1
UCEC	MEK1 →	+0.465	+3.169	.006	.019	3	1
UCEC	p62 Lck ligand →	+0.384	+2.179	.011	.034	3	1
UCEC	Annexin-1 →	+0.492	+3.019	.045	.019	3	1
UCEC	XBP1 →	-0.187	-2.308	.004	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

A-Raf_pS299 by TSPO2 expression — UCEC

Explore this box plot interactively →