Across TCGA pan-cancer cohorts, TSPEAR-AS2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TSPEAR-AS2’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where TSPEAR-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSPEAR-AS2 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
STAD, HNSC, and LIHC are the cancer types where TSPEAR-AS2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPEAR-AS2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.