TSPAN9

Across TCGA pan-cancer cohorts, TSPAN9 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TSPAN9 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TSPAN9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSPAN9 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where TSPAN9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.613	0.851	.002	41	view →
PDAC	OS	Median	All	0.466	0.615	.008	22	view →
LSCC	DFS	Median	All	0.505	0.992	.003	13	view →
COAD	DFS	Median	II,III,IV	1.000	0.884	.024	12	view →
LUAD	OS	Tertile	All	1.000	0.645	.015	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TSPAN9–CCRCC (DFS)

Open the CCRCC breakdown →