TSPAN9

Across TCGA patient cohorts, TSPAN9 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN9-associated genes across cancer lineages are ATM, HER3_pY1289, and INPP4B. Each is linked with TSPAN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN9-to-partner and partner-to-TSPAN9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TSPAN9-low versus TSPAN9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN9→partner) and Y-score (partner→TSPAN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.649	-2.115	.001	.019	3	2
UCEC	HER3_pY1289 →	+0.081	+2.142	.032	.010	3	1
UCEC	INPP4B →	-0.293	-2.999	.038	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.267	+2.321	.003	.033	3	1
UCEC	Notch1 →	+0.204	+2.807	<.001	.003	3	1
UCEC	p62 Lck ligand →	+0.492	+2.459	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by TSPAN9 expression — UCEC

Explore this box plot interactively →