TSPAN7

Across TCGA patient cohorts, TSPAN7 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN7-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and MEK1. Each is linked with TSPAN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN7-to-partner and partner-to-TSPAN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TSPAN7-low versus TSPAN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN7→partner) and Y-score (partner→TSPAN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.315	-3.321	.004	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.201	-2.102	.006	.019	3	1
UCEC	MEK1 →	+0.435	+2.999	.006	.035	3	1
UCEC	MSH2 →	-0.422	-3.295	<.001	.009	3	1
UCEC	MSH6 →	-0.531	-2.115	<.001	.019	3	1
UCEC	Myosin-IIa →	+0.173	+1.881	.045	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by TSPAN7 expression — UCEC

Explore this box plot interactively →