Across TCGA pan-cancer cohorts, TSPAN4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TSPAN4 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TSPAN4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSPAN4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where TSPAN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.485	0.874	<.001	34	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	17	view →
LSCC	DFS	Quartile	II,III,IV	0.512	0.938	.006	9	view →
CCRCC	OS	Median	All	1.000	0.890	.025	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TSPAN4 tumor-vs-normal RNA expression · all TSPAN4 data types