Across TCGA cell cohorts, TSPAN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,857 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSPAN4-associated GO terms across cancer lineages are Negative regulation of Rho protein signal transduction, Peptidyl-lysine oxidation, and Actin filament depolymerization. Each is linked with TSPAN4 in more than 14 cancer types. Because this analysis shows association rather than direction, both TSPAN4-to-partner and partner-to-TSPAN4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN4→partner) and Y-score (partner→TSPAN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of Rho protein signal transduction →	+0.183	+2.750	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.625	+2.649	<.001	<.001	3	14
LIVER	Actin filament depolymerization →	+0.179	+1.468	.003	.002	3	13
LUNG_SCLC	Keratinocyte development →	+0.793	+1.454	.003	.003	3	13
BONE	Positive regulation of cell-substrate adhesion →	+0.126	+1.207	<.001	<.001	3	12
SOFT_TISSUE	Regulation of endocytosis →	+0.087	+1.733	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,857 associations by consensus.

Exploration

TSPAN4 survival (RNA) · tumor vs normal (RNA) · all TSPAN4 data types