Across TCGA cell cohorts, TSPAN4 mutation is significantly associated with the mutation status of many other genes, with 486 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSPAN4-associated genes across cancer lineages are TMEM145, ZNF878, and ANKRD34A. Each is linked with TSPAN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSPAN4-to-partner and partner-to-TSPAN4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN4→partner) and Y-score (partner→TSPAN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM145 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	ZNF878 →	+5.321	+5.894	.002	.002	1	2
BLOOD_Leukemia	ANKRD34A →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	APCDD1 →	+4.000	+5.050	.008	.008	1	2
BLOOD_Leukemia	BRAF →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	CHAF1B →	+6.321	+6.321	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

Exploration

TSPAN4 survival (RNA) · tumor vs normal (RNA) · all TSPAN4 data types