TSPAN31

Across TCGA patient cohorts, TSPAN31 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN31-associated genes across cancer lineages are A-Raf_pS299, Lck, and MEK1. Each is linked with TSPAN31 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN31-to-partner and partner-to-TSPAN31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TSPAN31-low versus TSPAN31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN31→partner) and Y-score (partner→TSPAN31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.132	-2.459	.021	.020	3	1
UCEC	Lck →	+0.255	+3.584	.008	.002	3	1
UCEC	MEK1 →	+0.478	+2.459	.006	.020	3	1
UCEC	N-Ras →	-0.136	-2.446	.018	.020	3	1
UCEC	p62 Lck ligand →	+0.514	+3.179	.001	.010	3	1
UCEC	p70-S6K_pT389 →	-0.235	-2.999	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

A-Raf_pS299 by TSPAN31 expression — UCEC

Explore this box plot interactively →