TSPAN3

Across TCGA pan-cancer cohorts, TSPAN3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TSPAN3 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TSPAN3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TSPAN3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

STAD, BRCA, and BLCA are the cancer types where TSPAN3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.003	0.667	<.001	24	view →
BRCA	OS	Median	All	0.125	0.578	.005	16	view →
BLCA	OS	Median	II,III,IV	1.000	0.408	.045	3	view →
UCEC	DFS	Median	All	1.000	0.625	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TSPAN3–STAD (OS)

Open the STAD breakdown →