TSPAN3

Across TCGA pan-cancer cohorts, TSPAN3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TSPAN3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TSPAN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSPAN3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where TSPAN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.852	1.000	.030	12	view →
HNSC	OS	Quartile	All	0.259	1.000	.036	12	view →
PDAC	OS	Median	IV	0.381	0.951	.006	7	view →
GBM	DFS	Quartile	All	0.598	0.863	.019	4	view →
LUAD	DFS	Tertile	II,III,IV	0.393	0.780	.042	2	view →
LSCC	OS	Median	II,III,IV	1.000	0.810	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TSPAN3–COAD (DFS)

Open the COAD breakdown →