TSPAN3

Across TCGA patient cohorts, TSPAN3 protein abundance is significantly associated with the RNA expression of many other genes, with 10,423 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TSPAN3-associated genes across cancer lineages are SH3BGRL2, ADAMTS4, and DVL3. Each is linked with TSPAN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TSPAN3-to-partner and partner-to-TSPAN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSPAN3 versus SH3BGRL2 in HNSC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN3→partner) and Y-score (partner→TSPAN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BGRL2 →	+1.139	+0.559	<.001	.001	3	4
OV	ADAMTS4 →	-0.817	-0.746	<.001	<.001	3	3
OV	DVL3 →	-0.614	-0.502	.001	.008	3	3
HNSC	ARSI →	-0.901	-0.480	.005	.001	3	3
LUAD	TMEM132A →	-0.782	-0.696	<.001	.003	3	3
OV	EPYC →	-1.915	-0.564	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,423 associations by consensus.

TSPAN3 vs SH3BGRL2 — HNSC

Explore this scatter interactively →