TSPAN3

Across TCGA patient cohorts, TSPAN3 mutation is significantly associated with the RNA expression of many other genes, with 2,880 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN3-associated genes across cancer lineages are COPS5P1, LINC02436, and RNA5SP419. Each is linked with TSPAN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN3-to-partner and partner-to-TSPAN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS5P1 grouped by TSPAN3-low versus TSPAN3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN3→partner) and Y-score (partner→TSPAN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	COPS5P1 →	+0.058	+4.758	.004	.003	3	2
LUAD	LINC02436 →	+0.061	+5.523	<.001	<.001	3	2
UCEC	RNA5SP419 →	+1.132	+3.077	<.001	<.001	3	2
SKCM	LINC01809 →	+0.313	+5.680	<.001	.003	3	2
SKCM	LINC00851 →	+0.138	+5.037	<.001	.009	3	2
UCEC	TAF7 →	+0.693	+3.534	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,880 associations by consensus.

COPS5P1 by TSPAN3 expression — BLCA

Explore this box plot interactively →