TSPAN3

Across TCGA patient cohorts, TSPAN3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN3-associated genes across cancer lineages are JNK2, p62 Lck ligand, and Annexin_VII. Each is linked with TSPAN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN3-to-partner and partner-to-TSPAN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TSPAN3-low versus TSPAN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN3→partner) and Y-score (partner→TSPAN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.265	+2.321	.007	.035	3	1
UCEC	p62 Lck ligand →	+0.378	+2.817	.020	.036	3	1
UCEC	Annexin_VII →	-0.168	-2.321	.016	.035	3	1
UCEC	XBP1 →	-0.227	-2.321	.001	.034	3	1
UCEC	Caspase-8 →	-0.252	-2.973	.046	.035	3	1
UCEC	Chk2 →	-0.275	-2.321	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK2 by TSPAN3 expression — UCEC

Explore this box plot interactively →