TSPAN2

Across TCGA pan-cancer cohorts, TSPAN2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TSPAN2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TSPAN2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TSPAN2 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where TSPAN2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPAN2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.658	<.001	9	view →
LUAD	Female	All	−0.411	<.001	6	view →
LSCC	Male	All	−0.483	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TSPAN2–COAD

Open the COAD breakdown →