TSPAN2

Across TCGA patient cohorts, TSPAN2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN2-associated genes across cancer lineages are Di-Ras3, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with TSPAN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN2-to-partner and partner-to-TSPAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by TSPAN2-low versus TSPAN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN2→partner) and Y-score (partner→TSPAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.152	-2.807	.019	.003	3	2
UCEC	EGFR_pY1068 →	-0.245	-3.906	.025	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.161	-2.102	.028	.019	3	1
UCEC	MEK1 →	+0.385	+3.906	.016	<.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.409	-2.102	.037	.019	3	1
UCEC	PDCD4 →	-0.641	-2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Di-Ras3 by TSPAN2 expression — UCEC

Explore this box plot interactively →