TSPAN2

Across TCGA cell cohorts, TSPAN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,490 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TSPAN2-associated GO terms across cancer lineages are Proteasomal ubiquitin-independent protein catabolic process, Type II interferon-mediated signaling pathway, and Blood coagulation, fibrin clot formation. Each is linked with TSPAN2 in more than 12 cancer types. Because this analysis shows association rather than direction, both TSPAN2-to-partner and partner-to-TSPAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteasomal ubiquitin-independent protein catabolic process grouped by TSPAN2-low versus TSPAN2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN2→partner) and Y-score (partner→TSPAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Proteasomal ubiquitin-independent protein catabolic process →	+0.090	+1.588	<.001	<.001	3	13
BREAST	Type II interferon-mediated signaling pathway →	+0.232	+1.696	<.001	<.001	3	11
SOFT_TISSUE	Blood coagulation, fibrin clot formation →	+0.296	+0.923	.001	.005	2	12
SOFT_TISSUE	Maintenance of protein localization in organelle →	+0.119	+0.931	<.001	.005	3	11
STOMACH	Regulation of fibroblast proliferation →	+0.101	+1.427	<.001	.001	3	11
BREAST	Maintenance of protein location →	+0.104	+1.359	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,490 associations by consensus.

Proteasomal ubiquitin-independent protein catabolic process by TSPAN2 expression — BREAST

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