TSPAN2

Across TCGA cell cohorts, TSPAN2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSPAN2-associated genes across cancer lineages are CRYBA1, MSGN1, and ARMC3. Each is linked with TSPAN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN2-to-partner and partner-to-TSPAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBA1 grouped by TSPAN2-low versus TSPAN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN2→partner) and Y-score (partner→TSPAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRYBA1 →	+0.158	+3.232	<.001	.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.069	+3.345	<.001	.001	3	1
LARGE_INTESTINE	ARMC3 →	+0.412	+3.392	<.001	.006	3	1
LARGE_INTESTINE	CYYR1 →	+0.025	+3.256	<.001	.005	3	1
LARGE_INTESTINE	SLN →	+0.123	+3.706	.009	.002	3	1
LARGE_INTESTINE	SLC6A19 →	+1.338	+3.497	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

CRYBA1 by TSPAN2 expression — LARGE_INTESTINE

Explore this box plot interactively →