TSPAN18

Across TCGA patient cohorts, TSPAN18 mutation is significantly associated with the RNA expression of many other genes, with 646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN18-associated genes across cancer lineages are UBE2E2-AS1, DAPK3, and GPR25. Each is linked with TSPAN18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN18-to-partner and partner-to-TSPAN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2E2-AS1 grouped by TSPAN18-low versus TSPAN18-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN18→partner) and Y-score (partner→TSPAN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBE2E2-AS1 →	+0.149	+4.588	<.001	<.001	3	2
UCEC	DAPK3 →	+0.409	+2.447	.008	.001	3	2
UCEC	GPR25 →	+0.851	+3.501	<.001	.002	3	2
SKCM	NICN2P →	+0.071	+2.855	<.001	.003	3	2
UCEC	OAZ1 →	+0.364	+2.601	.004	.006	3	2
COAD	MCCD1 →	+0.145	+4.541	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 646 associations by consensus.

UBE2E2-AS1 by TSPAN18 expression — COAD

Explore this box plot interactively →