TSPAN18

Across TCGA cell cohorts, TSPAN18 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSPAN18-associated genes across cancer lineages are DMRTB1, OR1L3, and OR13C8. Each is linked with TSPAN18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN18-to-partner and partner-to-TSPAN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTB1 grouped by TSPAN18-low versus TSPAN18-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN18→partner) and Y-score (partner→TSPAN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L3 →	+0.028	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.036	+5.662	<.001	.002	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.126	+4.930	<.001	.001	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

DMRTB1 by TSPAN18 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →