TSPAN16

Across TCGA pan-cancer cohorts, TSPAN16 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TSPAN16 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TSPAN16 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TSPAN16 expression acts as an unfavorable survival marker.

MESO, BLCA, and SCLC are the cancer types where TSPAN16 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.069	0.580	<.001	36	view →
BLCA	OS	Median	All	0.090	0.688	<.001	24	view →
SCLC	OS	Median	All	0.082	0.822	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TSPAN16–MESO (OS)

Open the MESO breakdown →