TSPAN15

Across TCGA patient cohorts, TSPAN15 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN15-associated genes across cancer lineages are GAPDH, EGFR, and PCNA. Each is linked with TSPAN15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN15-to-partner and partner-to-TSPAN15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by TSPAN15-low versus TSPAN15-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN15→partner) and Y-score (partner→TSPAN15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.702	+3.008	.007	.019	3	2
UCEC	EGFR →	-0.156	-2.000	.009	.030	3	2
UCEC	PCNA →	+0.167	+2.000	.039	.030	3	2
UCEC	ATM →	-0.401	-1.765	.018	.014	3	2
UCEC	14-3-3_beta →	-0.100	-1.680	.008	.042	3	1
UCEC	A-Raf_pS299 →	-0.133	-3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

GAPDH by TSPAN15 expression — COAD

Explore this box plot interactively →