TSPAN14

Across TCGA pan-cancer cohorts, TSPAN14 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TSPAN14 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TSPAN14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TSPAN14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, KICH, and UCEC are the cancer types where TSPAN14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.514	0.844	.002	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCEC	DFS	Median	All	1.000	0.629	.025	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TSPAN14–OV (OS)

Open the OV breakdown →