TSPAN14

Across TCGA pan-cancer cohorts, TSPAN14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TSPAN14 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TSPAN14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSPAN14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where TSPAN14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.502	0.918	<.001	54	view →
HNSC	DFS	Quartile	II,III,IV	0.871	0.541	.005	20	view →
LSCC	DFS	Median	III,IV	1.000	0.624	.013	15	view →
LUAD	OS	Median	III,IV	0.228	0.624	.022	3	view →
GBM	DFS	Median	All	0.415	0.221	.042	2	view →
CCRCC	OS	Median	III,IV	1.000	0.353	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TSPAN14–PDAC (DFS)

Open the PDAC breakdown →