TSPAN14

Across TCGA patient cohorts, TSPAN14 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN14-associated genes across cancer lineages are eEF2, eIF4E, and FoxM1. Each is linked with TSPAN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN14-to-partner and partner-to-TSPAN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TSPAN14-low versus TSPAN14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN14→partner) and Y-score (partner→TSPAN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.276	+1.874	.044	.049	3	2
UCEC	eIF4E →	+0.179	+3.013	.027	.018	3	2
UCEC	FoxM1 →	+0.244	+2.087	.014	.005	3	2
UCEC	Rad50 →	-0.209	-2.087	.024	.005	3	2
UCEC	ASNS →	+0.396	+1.700	.004	.042	3	2
UCEC	14-3-3_beta →	-0.091	-3.295	.018	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eEF2 by TSPAN14 expression — UCEC

Explore this box plot interactively →