TSPAN13

Across TCGA pan-cancer cohorts, TSPAN13 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TSPAN13’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TSPAN13 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TSPAN13 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

PDAC, LUAD, and CCRCC are the cancer types where TSPAN13 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPAN13 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	III,IV	+1.570	<.001	10	view →
LUAD	Male	II,III,IV	+0.415	<.001	5	view →
CCRCC	Male	III,IV	+0.441	.020	2	view →
LSCC	All	All	−0.124	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TSPAN13–PDAC

Open the PDAC breakdown →