TSPAN13

Across TCGA patient cohorts, TSPAN13 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN13-associated genes across cancer lineages are FoxM1, INPP4B, and Ku80. Each is linked with TSPAN13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN13-to-partner and partner-to-TSPAN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TSPAN13-low versus TSPAN13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN13→partner) and Y-score (partner→TSPAN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.300	+2.179	.016	.034	3	1
UCEC	INPP4B →	-0.326	-2.446	.037	.020	3	1
UCEC	Ku80 →	+0.280	+3.179	.014	.010	3	1
UCEC	p27_pT157 →	-0.071	-2.459	.011	.020	3	1
UCEC	Rab11 →	-0.139	-2.459	.047	.020	3	1
UCEC	STAT3_pY705 →	-0.325	-2.459	.010	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FoxM1 by TSPAN13 expression — UCEC

Explore this box plot interactively →