TSNAXIP1

Across TCGA patient cohorts, TSNAXIP1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSNAXIP1-associated genes across cancer lineages are mTOR_pS2448, eIF4E, and A-Raf_pS299. Each is linked with TSNAXIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSNAXIP1-to-partner and partner-to-TSNAXIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TSNAXIP1-low versus TSNAXIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSNAXIP1→partner) and Y-score (partner→TSNAXIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.118	-1.680	.034	.042	3	3
UCEC	eIF4E →	+0.220	+3.807	.005	<.001	3	2
UCEC	A-Raf_pS299 →	-0.127	-3.700	.004	.001	3	2
UCEC	FASN →	+0.452	+1.415	.002	.046	3	2
UCEC	P-Cadherin →	-0.115	-2.449	.033	.019	3	2
UCEC	Shc_pY317 →	-0.169	-1.415	.003	.046	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

mTOR_pS2448 by TSNAXIP1 expression — UCEC

Explore this box plot interactively →