Across TCGA patient cohorts, TSN mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSN-associated genes across cancer lineages are Rad50, ERK2, and Acetyl-a-Tubulin-Lys40. Each is linked with TSN in more than 1 cancer types. Because this analysis shows association rather than direction, both TSN-to-partner and partner-to-TSN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSN→partner) and Y-score (partner→TSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.241	-2.584	.032	.011	3	2
UCEC	ERK2 →	+0.191	+3.000	.033	.036	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.652	+2.584	.005	.011	3	1
UCEC	PDK1 →	+0.102	+3.000	.041	.036	3	1
UCEC	PRDX1 →	+0.207	+3.321	.031	.010	3	1
UCEC	Annexin-1 →	+0.627	+3.019	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TSN survival (RNA) · tumor vs normal (RNA) · all TSN data types