TSKS

Across TCGA pan-cancer cohorts, TSKS Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TSKS data layer compared with 18 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TSKS Mutation is associated with better overall survival. In most high-consensus cancer types, elevated TSKS expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, SARC, and MESO are the cancer types where TSKS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.456	.009	24	view →
SARC	DFS	Median	All	0.198	0.616	.002	9	view →
MESO	DFS	Median	II,III,IV	0.039	0.407	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
COAD	OS	Median	All	0.507	0.802	.018	3	view →
LUSC	DFS	Median	All	0.682	0.380	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TSKS–UCEC (OS)

Open the UCEC breakdown →