TSHZ1

Across TCGA patient cohorts, TSHZ1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSHZ1-associated genes across cancer lineages are PDCD4, GAPDH, and Shc_pY317. Each is linked with TSHZ1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TSHZ1-to-partner and partner-to-TSHZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TSHZ1-low versus TSHZ1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ1→partner) and Y-score (partner→TSHZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.653	-3.576	<.001	.002	3	4
UCEC	GAPDH →	+0.512	+2.736	<.001	<.001	3	3
UCEC	Shc_pY317 →	-0.126	-1.369	.002	.003	3	3
UCEC	ATM →	-0.566	-2.362	<.001	<.001	3	3
COAD	ASNS →	+0.566	+3.321	<.001	.009	3	3
SKCM	Fibronectin →	+0.508	+2.000	.011	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

PDCD4 by TSHZ1 expression — COAD

Explore this box plot interactively →