TSHZ1

Across TCGA cell cohorts, TSHZ1 mutation is significantly associated with the RNA expression of many other genes, with 1,231 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSHZ1-associated genes across cancer lineages are PRR23B, R3HDML, and PRSS45P. Each is linked with TSHZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSHZ1-to-partner and partner-to-TSHZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23B grouped by TSHZ1-low versus TSHZ1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ1→partner) and Y-score (partner→TSHZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRR23B →	+0.013	+5.285	<.001	.003	3	2
BLOOD_Leukemia	R3HDML →	+0.008	+3.762	<.001	.007	3	2
BLOOD_Leukemia	PRSS45P →	+0.040	+2.855	<.001	.002	3	2
LARGE_INTESTINE	SCLY →	+0.793	+3.502	<.001	.001	3	2
LARGE_INTESTINE	CNOT10 →	+0.532	+3.502	<.001	.001	3	2
LARGE_INTESTINE	KIF26A →	+1.463	+3.169	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,231 associations by consensus.

PRR23B by TSHZ1 expression — STOMACH

Explore this box plot interactively →