Across TCGA patient cohorts, TSGA13 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSGA13-associated genes across cancer lineages are Tuberin, ATM, and 4E-BP1. Each is linked with TSGA13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSGA13-to-partner and partner-to-TSGA13 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSGA13→partner) and Y-score (partner→TSGA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.340	+2.817	.016	.036	3	1
UCEC	ATM →	-0.806	-3.000	<.001	.036	3	1
UCEC	4E-BP1 →	+0.377	+2.837	.007	.035	2	2
SKCM	Smad3 →	-0.193	-3.000	.034	.036	2	1
SKCM	CDK1_pY15 →	+0.427	+2.822	.008	.034	2	1
UCEC	MEK1 →	+0.500	+3.321	.009	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TSGA13 survival (RNA) · tumor vs normal (RNA) · all TSGA13 data types