TSGA10IP

Across TCGA patient cohorts, TSGA10IP mutation is significantly associated with the RNA expression of many other genes, with 1,482 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TSGA10IP-associated genes across cancer lineages are HSPE1P19, POLE2, and PARP2. Each is linked with TSGA10IP in more than 2 cancer types. Because this analysis shows association rather than direction, both TSGA10IP-to-partner and partner-to-TSGA10IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPE1P19 grouped by TSGA10IP-low versus TSGA10IP-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSGA10IP→partner) and Y-score (partner→TSGA10IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HSPE1P19 →	+0.650	+3.531	<.001	.007	3	3
SKCM	POLE2 →	+0.761	+3.198	<.001	.009	3	3
SKCM	PARP2 →	+0.848	+3.604	<.001	.001	3	3
LUAD	H2AC1 →	+0.886	+4.044	<.001	.002	3	2
CESC	RNY3P11 →	+0.560	+5.306	<.001	.006	3	2
LUAD	SNORD116-16 →	+0.505	+3.357	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,482 associations by consensus.

HSPE1P19 by TSGA10IP expression — LUAD

Explore this box plot interactively →