TSGA10IP

Across TCGA patient cohorts, TSGA10IP mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSGA10IP-associated genes across cancer lineages are IGFBP2, MEK1, and Notch1. Each is linked with TSGA10IP in more than 1 cancer types. Because this analysis shows association rather than direction, both TSGA10IP-to-partner and partner-to-TSGA10IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by TSGA10IP-low versus TSGA10IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSGA10IP→partner) and Y-score (partner→TSGA10IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.676	-2.999	.020	.035	3	1
UCEC	MEK1 →	+0.411	+2.700	.012	.006	3	1
UCEC	Notch1 →	+0.180	+2.000	.004	.032	3	1
UCEC	p62 Lck ligand →	+0.404	+2.331	.005	.019	3	1
UCEC	PDCD4 →	-0.442	-2.000	.037	.032	3	1
UCEC	PEA-15_pS116 →	+0.384	+2.000	.015	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IGFBP2 by TSGA10IP expression — UCEC

Explore this box plot interactively →