TSGA10

Across TCGA patient cohorts, TSGA10 mutation is significantly associated with the RNA expression of many other genes, with 3,588 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSGA10-associated genes across cancer lineages are RNA5SP198, DBIP2, and C9orf50. Each is linked with TSGA10 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSGA10-to-partner and partner-to-TSGA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by TSGA10-low versus TSGA10-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSGA10→partner) and Y-score (partner→TSGA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.384	+6.144	<.001	.001	3	3
SKCM	DBIP2 →	+0.133	+2.656	.003	.005	3	3
UCEC	C9orf50 →	-0.399	-1.584	<.001	<.001	3	2
UCEC	AKAP5 →	+0.291	+1.765	.003	<.001	3	2
UCEC	DNAH2 →	-0.604	-1.574	<.001	<.001	3	2
CESC	MIR4769 →	+0.474	+7.164	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,588 associations by consensus.

RNA5SP198 by TSGA10 expression — CESC

Explore this box plot interactively →