TSGA10

Across TCGA cell cohorts, TSGA10 mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSGA10-associated genes across cancer lineages are PRAMEF14, IL3, and PRAMEF10. Each is linked with TSGA10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSGA10-to-partner and partner-to-TSGA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF14 grouped by TSGA10-low versus TSGA10-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSGA10→partner) and Y-score (partner→TSGA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRAMEF14 →	+0.150	+3.887	<.001	.001	3	2
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

PRAMEF14 by TSGA10 expression — CNS

Explore this box plot interactively →