TSG101

Across TCGA pan-cancer cohorts, TSG101 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TSG101 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSG101 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TSG101 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where TSG101 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.882	0.663	.001	60	view →
UCEC	DFS	Median	II,III,IV	0.933	0.476	.001	18	view →
LUAD	DFS	Tertile	All	0.481	0.779	.009	14	view →
PDAC	OS	Quartile	III,IV	1.000	0.409	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TSG101–HNSC (DFS)

Open the HNSC breakdown →