TSFM

Across TCGA pan-cancer cohorts, TSFM mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TSFM data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TSFM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSFM expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

CCRCC, PDAC, and COAD are the cancer types where TSFM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.324	0.735	.011	14	view →
PDAC	OS	Median	II,III,IV	0.277	0.500	.008	13	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →
GBM	OS	Median	All	0.642	0.389	.016	4	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.872	.028	2	view →
LUAD	OS	Median	All	0.595	0.844	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TSFM–CCRCC (DFS)

Open the CCRCC breakdown →