TSFM

Across TCGA patient cohorts, TSFM protein abundance is significantly associated with the RNA expression of many other genes, with 17,704 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TSFM-associated genes across cancer lineages are LHFPL6, COL8A1, and PLPP7. Each is linked with TSFM in more than 7 cancer types. Because this analysis shows association rather than direction, both TSFM-to-partner and partner-to-TSFM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSFM versus LHFPL6 in BRCA, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSFM→partner) and Y-score (partner→TSFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LHFPL6 →	-1.300	-0.480	<.001	<.001	3	8
OV	COL8A1 →	-1.529	-0.448	<.001	<.001	3	7
CCRCC	PLPP7 →	-0.542	-0.333	.001	.004	3	7
OV	CFH →	-1.218	-0.506	.003	<.001	3	7
OV	IFFO1 →	-0.631	-0.295	.001	.002	3	6
OV	SYDE1 →	-0.998	-0.612	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,704 associations by consensus.

TSFM vs LHFPL6 — BRCA

Explore this scatter interactively →