TSFM

Across TCGA patient cohorts, TSFM mutation is significantly associated with the RNA expression of many other genes, with 191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSFM-associated genes across cancer lineages are LYZL1, RNU1-17P, and RNU6-1066P. Each is linked with TSFM in more than 1 cancer types. Because this analysis shows association rather than direction, both TSFM-to-partner and partner-to-TSFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL1 grouped by TSFM-low versus TSFM-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSFM→partner) and Y-score (partner→TSFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LYZL1 →	+0.056	+5.418	<.001	.005	3	1
CESC	RNU1-17P →	+0.378	+5.103	<.001	.008	3	1
CESC	RNU6-1066P →	+0.344	+5.418	.002	.005	3	1
CESC	RNA5SP198 →	+0.411	+6.144	<.001	.001	3	1
CESC	DNAJA1P1 →	+0.053	+5.306	<.001	.006	3	1
CESC	LINC00457 →	+0.058	+5.201	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 191 associations by consensus.

LYZL1 by TSFM expression — CESC

Explore this box plot interactively →