TSEN54

Across TCGA pan-cancer cohorts, TSEN54 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TSEN54 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TSEN54 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated TSEN54 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

OV and BRCA are the cancer types where TSEN54 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	III,IV	1.000	0.311	.042	6	view →
BRCA	DFS	Median	All	0.647	0.902	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TSEN54–OV (OS)

Open the OV breakdown →