TSEN54

Across TCGA pan-cancer cohorts, TSEN54 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TSEN54 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSEN54 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TSEN54 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where TSEN54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.792	0.977	<.001	53	view →
PDAC	OS	Median	II,III,IV	0.417	0.624	<.001	26	view →
LSCC	DFS	Median	II,III,IV	0.885	0.539	.005	7	view →
CCRCC	DFS	Median	All	1.000	0.644	.006	4	view →
UCEC	DFS	Tertile	All	1.000	0.916	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TSEN54–HNSC (OS)

Open the HNSC breakdown →