TSEN54

Across TCGA cell cohorts, TSEN54 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,603 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TSEN54-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Leading strand elongation, and Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with TSEN54 in more than 14 cancer types. Because this analysis shows association rather than direction, both TSEN54-to-partner and partner-to-TSEN54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by TSEN54-low versus TSEN54-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSEN54→partner) and Y-score (partner→TSEN54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.208	+1.122	<.001	<.001	3	15
BONE	Leading strand elongation →	+0.159	+0.934	<.001	.001	3	15
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.227	+1.201	<.001	.001	3	14
BONE	Telomeric loop disassembly →	+0.142	+1.003	.001	.002	3	13
LUNG_NSCLC_LUSC	Regulation of collagen metabolic process →	-0.174	-0.669	<.001	.001	3	13
SOFT_TISSUE	Recombinational repair →	+0.089	+1.187	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,603 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by TSEN54 expression — BONE

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