TSEN54

Across TCGA cell cohorts, TSEN54 mutation is significantly associated with the mutation status of many other genes, with 423 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSEN54-associated genes across cancer lineages are EFEMP2, MYBPC1, and PRRC2A. Each is linked with TSEN54 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSEN54-to-partner and partner-to-TSEN54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EFEMP2 grouped by TSEN54-low versus TSEN54-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSEN54→partner) and Y-score (partner→TSEN54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EFEMP2 →	+4.857	+4.297	.009	.009	1	3
OVARY	MYBPC1 →	+4.415	+4.977	.007	.007	1	3
BREAST	PRRC2A →	+2.857	+4.142	.008	.008	1	2
BREAST	COL6A6 →	+2.857	+4.142	.008	.008	1	2
OVARY	RBM19 →	+4.415	+4.977	.007	.007	1	2
SKIN	ERVMER34-1 →	+4.239	+5.053	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 423 associations by consensus.

EFEMP2 by TSEN54 expression — BREAST

Explore this box plot interactively →