TSEN34

Across TCGA patient cohorts, TSEN34 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSEN34-associated genes across cancer lineages are IRS1, MEK1, and Shc_pY317. Each is linked with TSEN34 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSEN34-to-partner and partner-to-TSEN34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by TSEN34-low versus TSEN34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSEN34→partner) and Y-score (partner→TSEN34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+0.328	+3.169	.003	.020	3	1
UCEC	MEK1 →	+0.531	+3.169	.008	.020	3	1
UCEC	Shc_pY317 →	-0.189	-3.169	.023	.020	3	1
UCEC	BRD4 →	+0.387	+2.818	.008	.035	3	1
UCEC	4E-BP1 →	+0.566	+2.837	<.001	.035	2	1
UCEC	Di-Ras3 →	-0.183	-3.169	.025	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IRS1 by TSEN34 expression — UCEC

Explore this box plot interactively →