TSEN2

Across TCGA pan-cancer cohorts, TSEN2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TSEN2’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TSEN2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TSEN2 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

PDAC, CCRCC, and LSCC are the cancer types where TSEN2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSEN2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.506	.012	4	view →
CCRCC	All	All	−0.170	.039	2	view →
LSCC	All	All	+0.111	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TSEN2–PDAC

Open the PDAC breakdown →